ABSTRACT
Acantholytic squamous cell carcinoma (ASCC) is an uncommon variant of SCC. It was first described by Lever in 1947. It usually develops on sun-exposed areas of older-aged individuals. Histologically, the tumor consists of a nodular, epidermal-derived proliferation that forms islands like structures. At least focally or sometimes extensively, the tumor cells show a loss of cell cohesion within the central gland-like or tubular spaces. The lesions present as slowly growing scaly and occasionally ulcerated papules or plaques. Areas of acantholysis may produce large intraepidermal cavities which may extend to the adjacent follicular structures. ASCC is rarely seen in the oral cavity. Here, we report an unusual case of ASCC of the oral cavity, which was initially misinterpreted as angiosarcoma on histopathology. Then, on immunohistochemistry, ASCC was confirmed.
ABSTRACT
Background & objectives: The present study was undertaken to find out a new easy method in the diagnosis of malaria by centrifuged buffy coat smear, which was found to be a feasible and reasonable procedure. Methods: Blood samples collected from 120 patients suspected of malaria were subjected to all three diagnostic modalities—peripheral blood smear (PS), centrifuged buffy coat smear (CBCS) and antigen detection test using pLDH and aldolase (AG). Results: The results of various methods were compared. It was seen that addition of centrifugation (i.e. CBCS) to conventional method of PS (i.e. thick and thin smears) improved its sensitivity from 85 to 93.3%. Antigen detection and CBCS were found superior to PS in sensitivity. CBCS gives combined sensitivity and specificity of both antigen and PS. Conclusion: CBCS is as sensitive as antigen test and as specific as PS in species identification. It is a reasonable and feasible procedure too.
ABSTRACT
A case of a female patient aged 60 yrs, with metaplastic carcinoma of the breast which is a rare neoplasm is presented. Although it is a tumor of the ductal type, the predominant component of the neoplasm has an appearance other than glandular pattern and more in keeping with other cell types. Metaplastic carcinoma runs a very aggressive course and bears an unfavourable prognosis.
Subject(s)
Breast Neoplasms/pathology , Carcinoma, Ductal/pathology , Carcinosarcoma/pathology , Diagnosis, Differential , Female , Humans , Metaplasia , Middle AgedABSTRACT
In the growing knowledge of rare interesting tumors, the cotyledonoid leiomyoma is a tumor with an alarming appearance, of benign nature, but dealt with undue severity. We report a case of cotyledonoid leiomyoma in a 40 yr old female who presented with urinary retention and in whom a clinical diagnosis of uterine fibroid was made. On laparotomy, friable nodules were seen in the lower part of the uterus. Hence the diagnosis of sarcoma was considered and total abdominal hysterectomy with unilateral salpingo-oopherectomy was done. The friable nodules were removed piecemeal. Microscopic examination revealed nodules of bland looking smooth muscle cells arranged in-interlacing fascicles with perinodular hydropic degeneration. Necrosis or nuclear atypia was not seen. Increased awareness of this grossly alarming variant of benign leiomyoma can help avoid over treatment.